Brussels scientists advance Alzheimer’s research

Summary

Researchers at the Interuniversity Institute of Bioinformatics in Brussels have developed a method to predict the dynamics of proteins that play a role in diseases like Alzheimer’s

First results of Interuniversity Institute of Bioinformatics

Researchers at the Interuniversity Institute of Bioinformatics (IB)² in Brussels have developed a method to predict the dynamics of proteins that play a role in diseases like Alzheimer’s. The method has been labelled “DynaMine”.

The research team, led by professor Wim Vranken, succeeded in predicting where the main chain of proteins is more or less rigid, using only their amino acid sequence. By providing info in the dynamics of all known proteins, scientists can get an insight into the movements during the evolution of similar proteins in different organisms, their rigidness or flexibility and variable behaviour. These characteristics used to be a “grey zone” in research.

Diseases like, for example, Alzheimer’s are caused by the “sticking together” of proteins, in which these characteristics play an important role. The predictions via DynaMine could help to design new proteins, with adapted characteristics.

The method is the first result of a co-operation between different research groups in the (IB)2, established last October.

Three-month old Brussels research group establishes its first success.

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